Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids

0564844 - ÚOCHB 2023 RIV CH eng J - Článek v odborném periodiku
Szczurowska, Ewa - Szánti-Pintér, Eszter - Randáková, Alena - Jakubík, Jan - Kudová, Eva
Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids.
International Journal of Molecular Sciences. Roč. 23, č. 21 (2022), č. článku 13075. E-ISSN 1422-0067
Grant CEP: GA MŠMT(CZ) LX22NPO5104
Institucionální podpora: RVO:61388963 ; RVO:67985823
Klíčová slova: neurosteroids * neuroactive steroids * cholesterol * muscarinic receptors * allosteric modulation
Obor OECD: Biochemistry and molecular biology; Physiology (including cytology) (FGU-C)
Impakt faktor: 5.6, rok: 2022
Způsob publikování: Open access
https://doi.org/10.3390/ijms232113075

Muscarinic acetylcholine receptors are membrane receptors involved in many physiological processes. Malfunction of muscarinic signaling is a cause of various internal diseases, as well as psychiatric and neurologic conditions. Cholesterol, neurosteroids, neuroactive steroids, and steroid hormones are molecules of steroid origin that, besides having well-known genomic effects, also modulate membrane proteins including muscarinic acetylcholine receptors. Here, we review current knowledge on the allosteric modulation of muscarinic receptors by these steroids. We give a perspective on the research on the non-genomic effects of steroidal compounds on muscarinic receptors and drug development, with an aim to ultimately exploit such knowledge.
Trvalý link: https://hdl.handle.net/11104/0336401