Počet záznamů: 1
Nucleophilic tetrafluoroethylation of carbonyl compounds with fluorinated sulfones
- 1.0443178 - ÚOCHB 2016 RIV CH eng J - Článek v odborném periodiku
Václavík, Jiří - Chernykh, Yana - Jurásek, Bronislav - Beier, Petr
Nucleophilic tetrafluoroethylation of carbonyl compounds with fluorinated sulfones.
Journal of Fluorine Chemistry. Roč. 169, Jan (2015), s. 24-31. ISSN 0022-1139. E-ISSN 1873-3328
Grant CEP: GA ČR GAP207/11/0421
Grant ostatní: GA MŠk(CZ) ED3.2.00/08.0144; GA MŠk(CZ) LM2010005
Institucionální podpora: RVO:61388963
Klíčová slova: fluorine * tetrafluoroethylation * sulfones * nucleophilic addition * carbonyl compounds
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 2.213, rok: 2015
Global interest in the "CF2CF2" building blocks (tetrafluoroethylene, tetrafluoroethyl) is still rather marginal. One of the main reasons is the lack of efficient and selective tetrafluoroethylation reagents. In this context, we present here three new reagents (PhSO2CF2CF2R, R = SiMe3, SiEt3 and H) capable of nucleophilic addition to carbonyl compounds, thus affording rare alcohols containing the CF2CF2 motif. The experimental observations are complemented with a brief computational study which confirmed that the reactivity of the nudeophilic reagents is strongly dependent on electronic properties of substituents on both ends of the CF2CF2 group.
Trvalý link: http://hdl.handle.net/11104/0245925
Počet záznamů: 1