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Nucleophilic tetrafluoroethylation of carbonyl compounds with fluorinated sulfones

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    0443178 - ÚOCHB 2016 RIV CH eng J - Článek v odborném periodiku
    Václavík, Jiří - Chernykh, Yana - Jurásek, Bronislav - Beier, Petr
    Nucleophilic tetrafluoroethylation of carbonyl compounds with fluorinated sulfones.
    Journal of Fluorine Chemistry. Roč. 169, Jan (2015), s. 24-31. ISSN 0022-1139
    Grant CEP: GA ČR GAP207/11/0421
    Grant ostatní:GA MŠk(CZ) ED3.2.00/08.0144; GA MŠk(CZ) LM2010005
    Institucionální podpora: RVO:61388963
    Klíčová slova: fluorine * tetrafluoroethylation * sulfones * nucleophilic addition * carbonyl compounds
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.213, rok: 2015

    Global interest in the "CF2CF2" building blocks (tetrafluoroethylene, tetrafluoroethyl) is still rather marginal. One of the main reasons is the lack of efficient and selective tetrafluoroethylation reagents. In this context, we present here three new reagents (PhSO2CF2CF2R, R = SiMe3, SiEt3 and H) capable of nucleophilic addition to carbonyl compounds, thus affording rare alcohols containing the CF2CF2 motif. The experimental observations are complemented with a brief computational study which confirmed that the reactivity of the nudeophilic reagents is strongly dependent on electronic properties of substituents on both ends of the CF2CF2 group.
    Trvalý link: http://hdl.handle.net/11104/0245925
     
Počet záznamů: 1