SIFT-MS quantification of several breath biomarkers of inflammatory bowel disease, IBD: A detailed study of the ion chemistry

0462216 - ÚFCH JH 2017 RIV NL eng J - Článek v odborném periodiku
Brůhová Michalčíková, R. - Dryahina, Kseniya - Španěl, Patrik
SIFT-MS quantification of several breath biomarkers of inflammatory bowel disease, IBD: A detailed study of the ion chemistry.
International Journal of Mass Spectrometry. Roč. 396, FEB 2016 (2016), s. 35-41. ISSN 1387-3806. E-ISSN 1873-2798
Grant CEP: GA ČR GA13-28882S
Institucionální podpora: RVO:61388955
Klíčová slova: Selected ion flow tube mass spectrometry * Ion molecule reactions * Three body association
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Impakt faktor: 1.702, rok: 2016

Several compounds were previously identified as being present in modified concentrations in the breath of patients with inflammatory bowel diseases, IBD: 2-methylpentane, 1,3,5-triazine, trans-2-octene, cis-2-nonen-1-ol, 2′-methylacetophenone, 1-heptene and 2-hexanone. A selected ion flow tube, SIFT, study has thus been carried out of the reactions of H3O+, NO+ and O2+radical dot with these volatile organic compounds. The rate constants and product ion branching ratios of the primary reactions including three body association rate constants, describing the rate of hydration, were obtained. The results of this study allow accurate SIFT-MS quantification of concentrations of these compounds in exhaled breath of IBD patients with the ultimate aim of establishing their use as non-invasive biomarkers of the disease activity.

Trvalý link: http://hdl.handle.net/11104/0261707