0601919 - MBÚ 2025 RIV GB eng J - Článek v odborném periodiku
Rajsiglová, Lenka - Babič, Michal - Krausová, Kateřina - Lukáč, Pavol - Kalkusová, K. - Táborská, P. - Sojka, L. - Bartůňková, J. - Stakheev, Dmitry - Vannucci, Luca - Smrž, Daniel
Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy.
Journal of Immunotoxicology. Roč. 21, č. 1 (2024), č. článku 2416988. ISSN 1547-691X. E-ISSN 1547-6901
Grant CEP: GA MZd(CZ) NU23-08-00071; GA MŠMT LX22NPO5102
Institucionální podpora: RVO:61388971 ; RVO:61389013
Klíčová slova: iron-oxide nanoparticles * dendritic cells * establishment * expression * antigen * induce * death * Nanoparticles * cancer cells * immunogenic cell death * macrophages * dendritic cells * T-cells
Obor OECD: Immunology; Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials (UMCH-V)
Impakt faktor: 2.4, rok: 2023 ; AIS: 0.548, rok: 2023
Způsob publikování: Open access
Web výsledku:
https://www.tandfonline.com/doi/full/10.1080/1547691X.2024.2416988DOI: https://doi.org/10.1080/1547691X.2024.2416988

Nanoparticles are commonly used in diagnostics and therapy. They are also increasingly being implemented in cancer immunotherapy because of their ability to deliver drugs and modulate the immune system. However, the effect of nanoparticles on immune cells involved in the anti-tumor immune response is not well understood. The study reported here showed that nickel-doped maghemite nanoparticles (FN NP) are differentially cytotoxic to cultured mouse and human cancer cell lines, causing their death without negatively impacting the subsequent anticancer immune response. It also found that FN NP induced cell death in the mouse colorectal cancer cell line CT26 and human prostate cancer cell line PC-3, but not in the human prostate cancer cell line LNCaP. The induced cancer cell death did not affect the phenotype and responsivity of the isolated mouse peritoneal macrophages, or ex vivo-generated mouse bone marrow-derived, or human monocyte-derived dendritic cells. Additionally, the induced cancer cell death did not prevent the ex vivo-generated mouse or human dendritic cells from stimulating lymphocytes and enriching cell cultures with cancer cell-reactive T-cells. In conclusion, this study shows that FN NP could be a valuable platform for targeting cancer cells without causing immunosuppressive effects on the subsequent anticancer immune response.
Trvalý link: https://hdl.handle.net/11104/0359147


Vědecká data: https://pubmed.ncbi.nlm.nih.gov/39484726/