The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case-Control Studies in Irish and Czech Populations

0568597 - ÚEM 2023 RIV CH eng J - Článek v odborném periodiku
Mukherjee, M. - Ashfield, N. - Vodičková, Ludmila - Vymetálková, Veronika - Levý, M. - Liška, V. - Brůha, Jan - Bendová, Petra - O'Sullivan, J. - Doherty, G. - Sheahan, K. - Nolan, B. - Vodička, Pavel - Hughes, D.
The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case-Control Studies in Irish and Czech Populations.
Nutrients. Roč. 14, č. 13 (2022), č. článku 2718. E-ISSN 2072-6643
Grant CEP: GA ČR(CZ) GA20-03997S; GA ČR(CZ) GA22-05942S; GA MZd(CZ) NV18-03-00199
Institucionální podpora: RVO:68378041
Klíčová slova: selenium * selenoprotein gene variation * selenium pathway * colorectal neoplasms * case-control cohorts
Obor OECD: Genetics and heredity (medical genetics to be 3)
Impakt faktor: 5.9, rok: 2022
Způsob publikování: Open access
https://www.mdpi.com/2072-6643/14/13/2718

Background: Selenium manifests its biological effects through its incorporation into selenoproteins, which play several roles in countering oxidative and inflammatory responses implicated in colorectal carcinogenesis. Selenoprotein genetic variants may contribute to colorectal cancer (CRC) development, as we previously observed for SNP variants in a large European prospective study and a Czech case-control cohort. Methods: We tested if significantly associated selenoprotein gene SNPs from these studies were also associated with CRC risk in case-control studies from Ireland (colorectal neoplasia, i.e., cancer and adenoma cases: 450, controls: 461) and the Czech Republic (CRC cases: 718, controls: 646). Genotyping of 23 SNPs (20 in the Irish and 13 in the Czechs) was performed by competitive specific allele-specific PCR (KASPar). Multivariable adjusted logistic regression was used to assess the associations with CRC development. Results: We found significant associations with an increased CRC risk for rs5859 (SELENOF) and rs2972994 (SELENOP) in the Irish cohort but only with rs4802034 (SELENOV) in the Czechs. Significant associations were observed for rs5859 (SELENOF), rs4659382 (SELENON), rs2972994 (SELENOP), rs34713741 (SELENOS), and the related Se metabolism gene variant rs2275129 (SEPHS1) with advanced colorectal neoplasia development. However, none of these findings retained significance after multiple testing corrections. Conclusions: Several SNPs previously associated with CRC risk were also associated with CRC or colorectal neoplasia development in either the Irish or Czech cohorts. Selenoprotein gene variation may modify CRC risk across diverse European populations, although the specific variants may differ.
Trvalý link: https://hdl.handle.net/11104/0339877