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Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society

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    0547223 - FGÚ 2022 RIV CH eng J - Článek v odborném periodiku
    Lucas, S. - Tencerová, Michaela - von der Weid, B. - Andersen, T. L. - Attané, C. - Behler-Janbeck, F. - Cawthorn, W. P. - Ivaska, K. K. - Naveiras, O. - Podgorski, I. - Reagan, M. R. - van der Eerden, B. C. J.
    Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society.
    Frontiers in Endocrinology. Roč. 12, Sep 27 (2021), č. článku 744527. ISSN 1664-2392. E-ISSN 1664-2392
    Grant CEP: GA ČR(CZ) GA20-03586S
    Grant ostatní: Novo Nordisk Fonden(DK) NNF20SA0066174
    Institucionální podpora: RVO:67985823
    Klíčová slova: bone marrow adiposity * bone marrow adipocytes * bone marrow stromal cells * biobanking * cell isolation protocols * international research networks * patient information * clinical studies
    Obor OECD: Endocrinology and metabolism (including diabetes, hormones)
    Impakt faktor: 5.555, rok: 2020
    Způsob publikování: Open access
    https://doi.org/10.3389/fendo.2021.744527

    Over the last two decades, increased interest of scientists to study bone marrow adiposity (BMA) in relation to bone and adipose tissue physiology has expanded the number of publications using different sources of bone marrow adipose tissue (BMAT). However, each source of BMAT has its limitations in the number of downstream analyses for which it can be used. Based on this increased scientific demand, the International Bone Marrow Adiposity Society (BMAS) established a Biobanking Working Group to identify the challenges of biobanking for human BMA-related samples and to develop guidelines to advance establishment of biobanks for BMA research. BMA is a young, growing field with increased interest among many diverse scientific communities. These bring new perspectives and important biological questions on how to improve and build an international community with biobank databases that can be used and shared all over the world. However, to create internationally accessible biobanks, several practical and legislative issues must be addressed to create a general ethical protocol used in all institutes, to allow for exchange of biological material internationally. In this position paper, the BMAS Biobanking Working Group describes similarities and differences of patient information (PIF) and consent forms from different institutes and addresses a possibility to create uniform documents for BMA biobanking purposes. Further, based on discussion among Working Group members, we report an overview of the current isolation protocols for human bone marrow adipocytes (BMAds) and bone marrow stromal cells (BMSCs, formerly mesenchymal), highlighting the specific points crucial for effective isolation. Although we remain far from a unified BMAd isolation protocol and PIF, we have summarized all of these important aspects, which are needed to build a BMA biobank. In conclusion, we believe that harmonizing isolation protocols and PIF globally will help to build international collaborations and improve the quality and interpretation of BMA research outcomes.
    Trvalý link: http://hdl.handle.net/11104/0323513

     
     
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