Zinc(II) niflumato complex with neocuproine: Synthesis, crystal structure, characterization and cytotoxic effects on human endometrial cell lines

0541773 - FZÚ 2022 RIV NL eng J - Článek v odborném periodiku
Smolko, L. - Špaková, I. - Klepcová, Z. - Dubayová, K. - Samoľová, Erika - Rabajdová, M. - Mareková, M.
Zinc(II) niflumato complex with neocuproine: Synthesis, crystal structure, characterization and cytotoxic effects on human endometrial cell lines.
Journal of Molecular Structure. Roč. 1237, Aug (2021), č. článku 130312. ISSN 0022-2860. E-ISSN 1872-8014
Grant CEP: GA MŠMT(CZ) LO1603; GA ČR(CZ) GA18-10504S
GRANT EU: European Commission(CZ) CZ.2.16/3.1.00/24510
Institucionální podpora: RVO:68378271
Klíčová slova: Zinc(II) complexes * NSAIDs * niflumic acid * fluorescence * antiproliferative activity * DNA-binding
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 3.841, rok: 2021
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.molstruc.2021.130312

Novel zinc niflumato complex with a composition of [Zn(neo)(nif)2] was prepared in crystalline form and characterized by elemental analysis and spectroscopic methods. According to the results of the single-crystal X-ray structural analysis the central Zn(II) atoms within the complex molecules are tetracoordinated by two oxygen atoms of nif ligands and two nitrogen atoms of chelate bonded neo. In addition, spectral binding studies performed on isolated DNA samples revealed higher affinity of the complex to the 12Z DNA, thus suggesting possible specific DNA sequence recognition.
Trvalý link: http://hdl.handle.net/11104/0319300