Early Detection of Pancreatic Cancer in Type 2 Diabetes Mellitus Patients Based on 1H NMR Metabolomics.

0540081 - ÚCHP 2022 RIV US eng J - Článek v odborném periodiku
Michálková, Lenka - Horník, Štěpán - Sýkora, Jan - Habartová, L. - Setnička, V. - Bunganič, B.
Early Detection of Pancreatic Cancer in Type 2 Diabetes Mellitus Patients Based on 1H NMR Metabolomics.
Journal of Proteome Research. Roč. 20, č. 3 (2021), s. 1744-1753. ISSN 1535-3893. E-ISSN 1535-3907
Institucionální podpora: RVO:67985858
Klíčová slova: pancreatic cancer * diabetes mellitus * pancreatogenic diabetes * NMR metabolomics
Obor OECD: Medical engineering
Impakt faktor: 5.370, rok: 2021
Způsob publikování: Open access s časovým embargem

The association of pancreatic cancer with type 2 diabetes mellitus was investigated by 1H NMR metabolomic analysis of blood plasma. Concentration data of 58 metabolites enabled discrimination of pancreatic cancer (PC) patients from healthy controls (HC) and long-term type 2 diabetes mellitus (T2DM) patients. A panel of eight metabolites was proposed and successfully tested for group discrimination. Furthermore, a prediction model for the identification of at-risk individuals for future development of pancreatic cancer was built and tested on recent-onset diabetes mellitus (RODM) patients. Six of 59 RODM samples were assessed as PC with an accuracy of more than 80%. The health condition of these individuals was re-examined, and in four cases, a correlation to the prediction was found. The current health condition can be retrospectively attributed to misdiagnosed pancreatogenic diabetes or to early-stage pancreatic cancer.
Trvalý link: http://hdl.handle.net/11104/0318607