A Preliminary Study of Modification of 7-Deazaadenine with a Complex of Osmium Tetroxide with 2,2 '-Bipyridine

0506772 - BFÚ 2020 RIV CZ eng C - Konferenční příspěvek (zahraniční konf.)
Vítová, Lada - Havran, Luděk - Fojta, Miroslav - Šedo, O. - Zdráhal, Z. - Vespalec, Radim
A Preliminary Study of Modification of 7-Deazaadenine with a Complex of Osmium Tetroxide with 2,2 '-Bipyridine.
XXXIV. Moderní elektrochemické metody sborník přednášek. Ústí nad Labem: Best servis, 2014 - (Navrátil, T.; Fojta, M.; Pecková, K.), Č. 2014 (2014), s. 228-231. ISBN 978-80-905221-2-1.
[Moderní Elektrochemické Metody /34./. Jetřichovice (CZ), 19.05.2014-23.05.2014]
Grant CEP: GA ČR GBP206/12/G151
Institucionální podpora: RVO:68081707
Klíčová slova: dna * bases * Electrochemical analysis
Obor OECD: Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Reactivity of a purine nucleic base analogue 7-deazaadenine (A*) in short oligodeoxynucleotide (ODN) towards an osmium tetroxide complex with 2,2'-bipyridine (Os, bipy) was investigated by means of electrochemistry, capillary electrophoresis and MALDI-TOF mass spectrometry. Electrochemical measurement, electrophoretic analyses and mass spectrometric analyses of reaction mixture proved that ODN with an A* residue yields an osmium adduct with properties similar to those exhibited by the well-known adduct of thymine.
Trvalý link: http://hdl.handle.net/11104/0297944