Novel scintillating nanocomposite for X-ray induced photodynamic therapy

0504746 - FZÚ 2020 RIV GB eng J - Článek v odborném periodiku
Procházková, Lenka - Pelikánová, I.T. - Mihóková, Eva - Dědic, R. - Čuba, V.
Novel scintillating nanocomposite for X-ray induced photodynamic therapy.
Radiation Measurements. Roč. 121, Feb (2019), s. 13-17. ISSN 1350-4487. E-ISSN 1879-0925
Grant CEP: GA ČR GA17-06479S
Institucionální podpora: RVO:68378271
Klíčová slova: nanocomposite * photodynamic therapy * singlet oxygen * zinc oxide * scintillator
Obor OECD: Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics
Impakt faktor: 1.512, rok: 2019
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.radmeas.2018.12.008

We synthesize a novel prospective nanocomposite material for X-ray induced photodynamic therapy. ZnO:Ga core is coated by the SiO2 shell facilitating a functionalization by a photosensitizer, protoporphyrin PpIX layer.By steady-state and time resolved spectroscopy we confirm the presence of energy transfer between the core and the photosensitizer, an essential requirement to induce a cytotoxic effect. Using the commercial chemical probe we also demonstrate the ability of prepared ZnO:Ga@SiO2-PpIX nanocomposite to generate singlet oxygen. Presented results show that this nanocomposite can be considered as a good candidate for potential application in X-ray induced photodynamic therapy.
Trvalý link: http://hdl.handle.net/11104/0296315