Počet záznamů: 1  

Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes

  1. 1. 0487732 - UFCH-W 2019 RIV US eng J - Článek v odborném periodiku
    Kulig, W. - Mikkolainen, H. - Olžyńska, Agnieszka - Jurkiewicz, Piotr - Cwiklik, Lukasz - Hof, Martin - Vattulainen, I. - Jungwirth, P. - Rog, T.
    Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes.
    Journal of Physical Chemistry Letters. Roč. 9, č. 5 (2018), s. 1118-1123 ISSN 1948-7185
    Grant CEP: GA ČR(CZ) GBP208/12/G016
    Institucionální podpora: RVO:61388955 ; RVO:61388963
    Klíčová slova: biological membranes * alcohols * cell membranes
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Obor OECD: Physical chemistry
    Impakt faktor: 9.353, rok: 2016

    Translocation of sterols between cellular membrane leaflets is of key importance in membrane organization, dynamics, and signaling. We present a novel translocation mechanism that differs in a unique manner from the established ones. The bobbing mechanism identified here is demonstrated for tail-oxidized sterols, but is expected to be viable for any molecule containing two polar centers at the opposite sides of the molecule. The mechanism renders translocation across a lipid membrane possible without a change in molecular orientation. For tail-oxidized sterols, the bobbing mechanism provides an exceptionally facile means to translocate these signaling molecules across membrane structures and may thus represent an important pathway in the course of their biological action.
    Trvalý link: http://hdl.handle.net/11104/0282365