Počet záznamů: 1  

A Eukaryote without a Mitochondrial Organelle

  1. 1.
    0486310 - UMG-J 2018 RIV GB eng J - Článek v odborném periodiku
    Karnkowska, A. - Vacek, V. - Zubáčová, Z. - Treitli, S.C. - Petrzelkova, R. - Eme, L. - Novák, L. - Žárský, V. - Barlow, L.D. - Herman, E.K. - Soukal, P. - Hroudová, Miluše - Doležal, P. - Stairs, C.W. - Roger, A. J. - Eliaš, M. - Dacks, J.B. - Vlček, Čestmír - Hampl, V.
    A Eukaryote without a Mitochondrial Organelle.
    Current Biology. Roč. 26, č. 10 (2016), s. 1274-1284. ISSN 0960-9822
    Grant CEP: GA MŠk(CZ) LQ1604; GA MŠk(CZ) ED1.1.00/02.0109; GA ČR GAP506/12/1010
    Institucionální podpora: RVO:68378050
    Klíčová slova: arginine dihydrolase pathway * tail-anchored proteins * fe-s cluster * trichomonas-vaginalis * entamoeba-histolytica * giardia-intestinalis * tritrichomonas-fetus * genome annotation * energy-metabolism * gene-transfer
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Obor OECD: Developmental biology
    Impakt faktor: 8.851, rok: 2016

    The presence of mitochondria and related organelles in every studied eukaryote supports the view that mitochondria are essential cellular components. Here, we report the genome sequence of a microbial eukaryote, the oxymonad Monocercomonoides sp., which revealed that this organism lacks all hallmark mitochondrial proteins. Crucially, the mitochondrial iron-sulfur cluster assembly pathway, thought to be conserved in virtually all eukaryotic cells, has been replaced by a cytosolic sulfur mobilization system (SUF) acquired by lateral gene transfer from bacteria. In the context of eukaryotic phylogeny, our data suggest that Monocercomonoides is not primitively amitochondrial but has lost the mitochondrion secondarily. This is the first example of a eukaryote lacking any form of a mitochondrion, demonstrating that this organelle is not absolutely essential for the viability of a eukaryotic cell.
    Trvalý link: http://hdl.handle.net/11104/0281161