Počet záznamů: 1  

Multifunctional energy landscape for a DNA G-quadruplex: An evolved molecular switch

  1. 1.
    0486065 - BFÚ 2018 RIV US eng J - Článek v odborném periodiku
    Cragnolini, T. - Chakraborty, D. - Šponer, Jiří - Derreumaux, P. - Pasquali, S. - Wales, D.J.
    Multifunctional energy landscape for a DNA G-quadruplex: An evolved molecular switch.
    Journal of Chemical Physics. Roč. 147, č. 15 (2017), č. článku 152715. ISSN 0021-9606
    Grant CEP: GA ČR(CZ) GA16-13721S
    Institucionální podpora: RVO:68081707
    Klíčová slova: telomeric g-quadruplex * gb1 hairpin peptide
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Obor OECD: Physical chemistry
    Impakt faktor: 2.843, rok: 2017

    We explore the energy landscape for a four-fold telomere repeat, obtaining interconversion pathways between six experimentally characterised G-quadruplex topologies. The results reveal a multi-funnel system, with a variety of intermediate configurations and misfolded states. This organisation is identified with the intrinsically multi-functional nature of the system, suggesting a new paradigm for the classification of such biomolecules and clarifying issues regarding apparently conflicting experimental results. Published by AIP Publishing.
    Trvalý link: http://hdl.handle.net/11104/0280952