Počet záznamů: 1  

Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs

  1. 1.
    0477557 - ÚOCHB 2018 RIV CH eng J - Článek v odborném periodiku
    Jiráček, Jiří - Žáková, Lenka
    Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs.
    Frontiers in Endocrinology. Roč. 8, Jul 27 (2017), č. článku 167. ISSN 1664-2392
    Grant CEP: GA ČR GA15-19018S
    Institucionální podpora: RVO:61388963
    Klíčová slova: insulin receptor * insulin binding * analog * diabetes * glucose
    Kód oboru RIV: CE - Biochemie
    Obor OECD: Biochemistry and molecular biology
    Impakt faktor: 3.519, rok: 2017

    A significant drawback of the exogenous administration of insulin to diabetics is the non-physiological profile of insulin action resulting in the insufficient suppression of hepatic glucose production, which is the main contributing factor to diabetic hyperglycemia under fasting conditions and the basis of the challenge to restore a more physiological glucose profile in diabetes. The insulin receptor (IR) exists in two alternatively spliced variants, IR-A and IR-B, with different tissue distribution. While peripheral tissues contain different proportions of both isoforms, hepatic cells almost exclusively contain IR-B. In this respect, IR-B-selective insulin analogs would be of great interest for their potential to restore more natural metabolic homeostasis in diabetes. Recent advances in the structural biology of insulin and IR have provided new clues for understanding the interaction of both proteins. This article discusses and offers some structural perspectives for the design of specific insulin analogs with a preferential binding to IR-B.
    Trvalý link: http://hdl.handle.net/11104/0273876