Počet záznamů: 1  

Strategies toward protecting group-free glycosylation through selective activation of the anomeric center

  1. 1.
    0477455 - ÚOCHB 2018 RIV DE eng J - Článek v odborném periodiku
    Downey, Alan Michael - Hocek, Michal
    Strategies toward protecting group-free glycosylation through selective activation of the anomeric center.
    Beilstein Journal of Organic Chemistry. Roč. 13, Jun 27 (2017), s. 1239-1279. ISSN 1860-5397. E-ISSN 1860-5397
    Grant CEP: GA TA ČR(CZ) TE01020028
    Grant ostatní: AV ČR(CZ) AP1501
    Program: Akademická prémie - Praemium Academiae
    Institucionální podpora: RVO:61388963
    Klíčová slova: glycosides * glycosylation * oligosaccharides * protecting groups
    Obor OECD: Organic chemistry
    Impakt faktor: 2.330, rok: 2017
    http://www.beilstein-journals.org/bjoc/articles/13/123

    Glycosylation is an immensely important biological process and one that is highly controlled and very efficient in nature. However, in a chemical laboratory the process is much more challenging and usually requires the extensive use of protecting groups to squelch reactivity at undesired reactive moieties. Nonetheless, by taking advantage of the differential reactivity of the anomeric center, a selective activation at this position is possible. As a result, protecting group-free strategies to effect glycosylations are available thanks to the tremendous efforts of many research groups. In this review, we showcase the methods available for the selective activation of the anomeric center on the glycosyl donor and the mechanisms by which the glycosylation reactions take place to illustrate the power these techniques.
    Trvalý link: http://hdl.handle.net/11104/0273804

     
     
Počet záznamů: 1