Počet záznamů: 1  

Role of Primary Cilia in Odontogenesis

  1. 1.
    0477095 - UZFG-Y 2018 RIV US eng J - Článek v odborném periodiku
    Hampl, Marek - Celá, Petra - Szabo-Rogers, H. L. - Kunová Bosáková, M. - Dosedělová, Hana - Krejčí, P. - Buchtová, Marcela
    Role of Primary Cilia in Odontogenesis.
    Journal of Dental Research. Roč. 96, č. 9 (2017), s. 965-974. ISSN 0022-0345
    Grant CEP: GA MŠk EF15_003/0000460; GA ČR(CZ) GA17-14886S
    Institucionální podpora: RVO:67985904
    Klíčová slova: craniofacial anomalies * growth/development * mineralized tissue/development
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Obor OECD: Developmental biology
    Impakt faktor: 5.380, rok: 2017

    Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis. The emerging evidence implicates primary cilia function in tooth development. Primary cilia are located in the dental epithelium and mesenchyme at early stages of tooth development and later during cell differentiation and production of hard tissues. The cilia are present when interactions between both the epithelium and mesenchyme are required for normal morphogenesis. As the primary cilium coordinates several signaling pathways essential for odontogenesis, ciliary defects can interrupt the latter process. Genetic or experimental alterations of cilia function lead to various developmental defects, including supernumerary or missing teeth, enamel and dentin hypoplasia, or teeth crowding. Moreover, dental phenotypes are observed in ciliopathies, including Bardet-Biedl syndrome, Ellis-van Creveld syndrome, Weyers acrofacial dysostosis, cranioectodermal dysplasia, and oral-facial-digital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both the early odontogenesis and later differentiation of hard tissue-producing cells. Here, we summarize the current evidence for the localization of primary cilia in dental tissues and the impact of disrupted cilia signaling on tooth development in ciliopathies.
    Trvalý link: http://hdl.handle.net/11104/0273484