Počet záznamů: 1  

Exploring the contribution of spatial navigation to cognitive functioning in older adults

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    0477002 - FGÚ 2018 RIV US eng J - Článek v odborném periodiku
    Laczó, J. - Andel, R. - Nedělská, Z. - Vyhnálek, M. - Vlček, Kamil - Crutch, S. - Harrison, J. - Hort, J.
    Exploring the contribution of spatial navigation to cognitive functioning in older adults.
    Neurobiology of Aging. Roč. 51, Mar (2017), s. 67-70. ISSN 0197-4580. E-ISSN 1558-1497
    Institucionální podpora: RVO:67985823
    Klíčová slova: Alzheimer's disease * mild cognitive impairment * Morris water maze * spatial navigation * hippocampus * neuropsychology
    Obor OECD: Neurosciences (including psychophysiology
    Impakt faktor: 4.454, rok: 2017

    Spatial navigation (SN) impairment is present early in Alzheimer's disease (AD). We tested whether SN performance, self-centered (egocentric) and world-centered (allocentric), was distinguishable from performance on established cognitive functions-verbal and nonverbal memory, executive and visuospatial function, attention/working memory, and language function. 108 older adults ( 53 cognitively normal [CN] and 55 with amnestic mild cognitive impairment [aMCI]) underwent neuropsychological examination and real-space navigation testing. Subset (n = 63) had automated hippocampal volumetry. In a factor analysis, allocentric and egocentric navigation tasks loaded highly onto the same factor with low loadings on other factors comprising other cognitive functions. In linear regression, performance on other cognitive functions was not, or was only marginally, associated with spatial navigation performance in CN or aMCI groups. After adjustment for age, gender, and education, right hippocampal volume explained 26% of the variance in allocentric navigation in aMCI group. In conclusion, spatial navigation, a known cognitive marker of early AD, may be distinguished from other cognitive functions. Therefore, its assessment along with other major cognitive functions may be highly beneficial in terms of obtaining a comprehensive neuropsychological profile.
    Trvalý link: http://hdl.handle.net/11104/0273401

     
     
Počet záznamů: 1  

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