Development of thiol-ene-based enzymatic microreactor array for drug metabolism study

0475707 - ÚIACH 2018 CZ eng A - Abstrakt
Přikryl, Jan - Lafleur, J. P. - Foret, František - Ertl, P.
Development of thiol-ene-based enzymatic microreactor array for drug metabolism study.
HPLC 2017. Final Program. Praha: Czech-In s. r. o., 2017. s. 264-265.
[International symposium on high performance liquid phase separations and related techniques /45./. 18.06.2017-22.06.2017, Praha]
Grant CEP: GA ČR(CZ) GBP206/12/G014
Grant ostatní: GA AV ČR(CZ) MSM200311601
Program: Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Institucionální podpora: RVO:68081715
Klíčová slova: microreactor * drug metabolism * thiol-enes * OSTE
Kód oboru RIV: CB - Analytická chemie, separace

In this work, we report on the design and fabrication of microfluidic device and monolithic column based on thiol-ene click chemistry. The device was used to mimic drug metabolism in a lab thanks to immobilized liver microsomes.
Trvalý link: http://hdl.handle.net/11104/0272355