Počet záznamů: 1

Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?

  1. 1.
    0475001 - FGU-C 2018 RIV IE eng J - Článek v odborném periodiku
    Tsenov, Grygoriy - Kubová, Hana - Mareš, Pavel
    Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?.
    Neuroscience Letters. Roč. 644, Mar 22 (2017), s. 1-4 ISSN 0304-3940
    Grant CEP: GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GAP302/10/0971; GA ČR(CZ) GA15-16605S
    Institucionální podpora: RVO:67985823
    Klíčová slova: status epilepticus * immature rats * pilocarpine * lithium chloride * paraldehyde * cortical epileptic afterdischarges
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 2.180, rok: 2016

    Role of lithium chloride and paraldehyde in acute changes after lithium-pilocarpine status epilepticus (SE) induced at postnatal day 12 was studied in 15-day-old rats. In addition to SE group four other groups were formed: naive animals without any injection, lithium chloride group, paraldehyde group and lithium-paraldehyde group. Cortical epileptic afterdischarges (CxADs) induced by increasing intensities of stimulation current were used as a measure of excitability. SE animals did not exhibit any change in duration of CxADs with increasing stimulation intensity in contrast to na ve control with a progressive prolongation of CxAD. LiCI group was similar to SE rats whereas paraldehyde and lithium-paraldehyde groups exhibited some progress in duration of ADs. Lithium chloride participates in short-term changes of CxADs after SE. Paraldehyde and combination of lithium paraldehyde are similar to na ve controls.
    Trvalý link: http://hdl.handle.net/11104/0271882