Počet záznamů: 1  

2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound

  1. 1.
    0473521 - MBU-M 2018 RIV US eng J - Článek v odborném periodiku
    Filippopoulou, K. - Papaevgeniou, N. - Lefakia, M. - Paraskevopoulou, A. - Biedermann, David - Křen, Vladimír - Chondrogianni, N.
    2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound.
    Free Radical Biology and Medicine. Roč. 103, FEB 2017 (2017), s. 256-267. ISSN 0891-5849
    Grant CEP: GA MŠk(CZ) LD15081
    Institucionální podpora: RVO:61388971
    Klíčová slova: 2,3-dehydrosilybin A/B * Anti-aging * Anti-aggregation
    Kód oboru RIV: CE - Biochemie
    Obor OECD: Biochemistry and molecular biology
    Impakt faktor: 6.020, rok: 2017

    Aging is an unavoidable process characterized by gradual failure of homeostasis that constitutes a critical risk factor for several age-related disorders. It has been unveiled that manipulation of various key pathways may decelerate the aging progression and the triggering of age-related diseases. As a consequence, the identification of compounds, preferably natural-occurring, administered through diet, with lifespan-extending, anti-aggregation and anti-oxidation properties that in parallel exhibit negligible side-effects is the main goal in the battle against aging. Here we analyze the role of 2,3-dehydrosilybin A/B (DHS A/B), a minor component of silymarin used in a plethora of dietary supplements. This flavonolignan is well-known for its anti-oxidative and neuroprotective properties, among others. We demonstrate that DHS A/B confers oxidative stress resistance not only in human primary cells but also in the context of a multi-cellular aging model, namely Caenorhabditis elegans (C. elegans) where it also promotes lifespan extension. We reveal that these DHS A/B outcomes are FGT-1 and DAF-16 dependent. We additionally demonstrate the anti-aggregation properties of DHS A/B in human cells of nervous origin but also in nematode models of Alzheimer's disease (AD), eventually leading to decelerated progression of AD phenotype. Our results identify DHS A/B as the active component of silymarin extract and propose DHS A/B as a candidate anti-aging and anti-aggregation compound.
    Trvalý link: http://hdl.handle.net/11104/0270644