Gene-specific sex effects on eosinophil infiltration in leishmaniasis

0472109 - ÚMG 2017 RIV GB eng J - Článek v odborném periodiku
Slapničková, Martina - Volkova, Valeriya - Čepičková, Marie - Kobets, Tetyana - Šíma, Matyáš - Svobodová, M. - Demant, P. - Lipoldová, Marie
Gene-specific sex effects on eosinophil infiltration in leishmaniasis.
Biology of Sex Differences. Roč. 7, podzim (2016), č. článku 59. E-ISSN 2042-6410
Grant CEP: GA ČR(CZ) GA14-30186S; GA ČR GP13-41002P; GA MŠMT LH12049; GA ČR GA16-22346S
Institucionální podpora: RVO:68378050
Klíčová slova: Leishmania major * Mouse model * Eosinophii infiltration * Genetic control * QTL * Sex influence
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.635, rok: 2016

Background: Sex influences susceptibility to many infectious diseases, including some manifestations of leishmaniasis. The disease is caused by parasites that enter to the skin and can spread to the lymph nodes, spleen, liver, bone marrow, and sometimes lungs. Parasites induce host defenses including cell infiltration, leading to protective or ineffective inflammation. These responses are often influenced by host genotype and sex. We analyzed the role of sex in the impact of specific gene loci on eosinophil infiltration and its functional relevance.
Trvalý link: http://hdl.handle.net/11104/0269454