Počet záznamů: 1  

Gene-specific sex effects on eosinophil infiltration in leishmaniasis

  1. 1.
    0472109 - UMG-J 2017 RIV GB eng J - Článek v odborném periodiku
    Slapničková, Martina - Volkova, Valeriya - Čepičková, Marie - Kobets, Tetyana - Šíma, Matyáš - Svobodová, M. - Demant, P. - Lipoldová, Marie
    Gene-specific sex effects on eosinophil infiltration in leishmaniasis.
    Biology of Sex Differences. Roč. 7, podzim (2016), č. článku 59. ISSN 2042-6410
    Grant CEP: GA ČR(CZ) GA14-30186S; GA ČR GP13-41002P; GA MŠk LH12049; GA ČR GA16-22346S
    Institucionální podpora: RVO:68378050
    Klíčová slova: Leishmania major * Mouse model * Eosinophii infiltration * Genetic control * QTL * Sex influence
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.635, rok: 2016

    Background: Sex influences susceptibility to many infectious diseases, including some manifestations of leishmaniasis. The disease is caused by parasites that enter to the skin and can spread to the lymph nodes, spleen, liver, bone marrow, and sometimes lungs. Parasites induce host defenses including cell infiltration, leading to protective or ineffective inflammation. These responses are often influenced by host genotype and sex. We analyzed the role of sex in the impact of specific gene loci on eosinophil infiltration and its functional relevance.
    Trvalý link: http://hdl.handle.net/11104/0269454