0466564 - ÚMCH 2017 RIV US eng J - Článek v odborném periodiku
Nakamura, H. - Koziolová, Eva - Chytil, Petr - Tsukigawa, K. - Fang, J. - Haratake, M. - Ulbrich, Karel - Etrych, Tomáš - Maeda, H.
Pronounced cellular uptake of pirarubicin versus that of other anthracyclines: comparison of HPMA copolymer conjugates of pirarubicin and doxorubicin.
Molecular Pharmaceutics. Roč. 13, č. 12 (2016), s. 4106-4115. ISSN 1543-8384. E-ISSN 1543-8392
Grant CEP: GA ČR(CZ) GA15-02986S; GA MŠMT(CZ) LO1507; GA MŠMT(CZ) ED1.1.00/02.0109
Grant ostatní: AV ČR,Japan Society for the Promotion of Science(CZ) JSPS-16-05
Program: Bilaterální spolupráce
Institucionální podpora: RVO:61389013
Klíčová slova: HPMA polymer conjugate * pirarubicin (THP) * doxorubicin (DOX)
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 4.440, rok: 2016

Many conjugates of water-soluble polymers with biologically active molecules were developed during the last two decades. Although, therapeutic effects of these conjugates are affected by the properties of carriers, the properties of the attached drugs appear more important than the same carrier polymer in this case. Pirarubicin (THP), a tetrahydropyranyl derivative of doxorubicin (DOX), demonstrated more rapid cellular internalization and potent cytotoxicity than DOX. Here, we conjugated the THP or DOX to N-(2-hydroxypropyl)methacrylamide copolymer via a hydrazone bond.
Trvalý link: http://hdl.handle.net/11104/0266313