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Biocompatible Size-Defined Dendrimer-Albumin Binding Protein Hybrid Materials as a Versatile Platform for Biomedical Applications

  1. 1.
    0462486 - MBÚ 2017 RIV DE eng J - Článek v odborném periodiku
    Malý, J. - Staněk, Ondřej - Frolík, J. - Malý, M. - Ennen, F. - Appelhans, D. - Semerádtová, A. - Wróbel, D. - Stofik, M. - Knapová, T. - Kuchař, Milan - Červenková Šťastná, Lucie - Čermák, Jan - Šebo, Peter - Malý, Petr
    Biocompatible Size-Defined Dendrimer-Albumin Binding Protein Hybrid Materials as a Versatile Platform for Biomedical Applications.
    Macromolecular Bioscience. Roč. 16, č. 4 (2016), s. 553-566. ISSN 1616-5187
    Grant CEP: GA ČR(CZ) GA15-05903S; GA MZe QJ1210041; GA MŠk(CZ) ED1.1.00/02.0109
    Institucionální podpora: RVO:61388971 ; RVO:86652036 ; RVO:67985858
    Klíčová slova: binding domain proteins * biohybrid structures * HSA
    Kód oboru RIV: CE - Biochemie; EB - Genetika a molekulární biologie (BTO-N)
    Impakt faktor: 3.238, rok: 2016

    For the design of a biohybrid structure as a ligand-tailored drug delivery system (DDS), it is highly sophisticated to fabricate a DDS based on smoothly controllable conjugation steps. This article reports on the synthesis and the characterization of biohybrid conjugates based on noncovalent conjugation between a multivalent biotinylated and PEGylated poly(amido amine) (PAMAM) dendrimer and a tetrameric streptavidin-small protein binding scaffold. This protein binding scaffold (SA-ABDwt) possesses nM affinity toward human serum albumin (HSA). Thus, well-defined biohybrid structures, finalized by binding of one or two HSA molecules, are available at each conjugation step in a controlled molar ratio.
    Trvalý link: http://hdl.handle.net/11104/0261954
     
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