Počet záznamů: 1  

Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.

  1. 1.
    0461601 - ÚEM 2017 RIV DE eng J - Článek v odborném periodiku
    Ambrož, Antonín - Vlková, Veronika - Rössner ml., Pavel - Rössnerová, Andrea - Švecová, Vlasta - Milcová, Alena - Pulkrabová, J. - Hajslová, J. - Velemínský Jr., M. - Solanský, Ivo - Šrám, Radim
    Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.
    International Journal of Hygiene and Environmental Health. Roč. 219, č. 6 (2016), s. 545-556. ISSN 1438-4639
    Grant CEP: GA ČR(CZ) GA13-13458S
    Institucionální podpora: RVO:68378041
    Klíčová slova: air pollution * benzo[a]pyrene * lipid peroxidation
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 4.643, rok: 2016

    Higher PM2.5 concentrations were found in Karvina than in CB in the summer 2013 (mean +/- SD: 20.41 +/- 6.28 vs. 9.45 +/- 3.62 mu g/m(3), P < 0.001), and in the winter 2014 (mean +/- SD: 53.67 +/- 19.76 vs. 27.96 +/- 12.34 mu g/m(3), P < 0.001). We observed significant differences in 15-F2t-IsoP levels between the summer and winter seasons in Karvina for newborns (mean +/- SD: 64.24 +/- 6.75 vs. 104.26 +/- 38.18 pg/ml plasma, respectively) (P < 0.001). Levels of 8-oxodG differed only in the winter season between localities, they were significantly higher (P <0.001) in newborns from Karvina in comparison with CB (mean SD: 5.70 +/- 2.94 vs. 4.23 +/- 1.51 nmol/mmol creatinine, respectively). The results of multivariate regression analysis in newborns from Karvina showed PM2.5 concentrations to be a significant predictor for 8-oxodG excretion, PM2.5 and B[a]P (benzo[a]pyrene) concentrations to be a significant predictor for 15-F2t-IsoP levels. The results of multivariate regression analysis in mothers showed PM2.5 concentrations to be a significant predictor of 8-oxodG levels. (C) 2016 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license.
    Trvalý link: http://hdl.handle.net/11104/0267480