Počet záznamů: 1  

Planar Functionalized Surfaces for Direct Immunoaffinity Desorption/Ionization Mass Spectrometry

  1. 1.
    0460136 - MBU-M 2017 RIV US eng J - Článek v odborném periodiku
    Pompach, Petr - Kavan, Daniel - Benada, Oldřich - Růžička, V. - Volný, M. - Novák, Petr
    Planar Functionalized Surfaces for Direct Immunoaffinity Desorption/Ionization Mass Spectrometry.
    Clinical Chemistry. Roč. 62, č. 1 (2016), s. 270-278. ISSN 0009-9147
    Grant CEP: GA MŠk LO1509; GA MŠk(CZ) EE2.3.30.0003; GA MŠk(CZ) ED1.1.00/02.0109
    Institucionální podpora: RVO:61388971
    Klíčová slova: TREATED METAL-SURFACE * IN-SITU ENRICHMENT * ELECTROSPRAY DEPOSITION
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 8.008, rok: 2016

    Recent studies show that the haptoglobin phenotype in individuals with diabetes mellitus is an important factor for predicting the risk of myocardial infarction, cardiovascular death, and stroke. Current methods for haptoglobin phenotyping include PCR and gel electrophoresis. A need exists for a reliable method for high-throughput clinical applications. Mass spectrometry (MS) can in principle provide fast phenotyping because haptoglobin a 1 and a 2, which define the phenotype, have different molecular masses. Because of the complexity of the serum matrix, an efficient and fast enrichment technique is necessary for an MS-based assay.
    Trvalý link: http://hdl.handle.net/11104/0260273