Počet záznamů: 1  

Cholesterol and fat lowering with hydrophobic polysaccharide derivatives

  1. 1.
    0457794 - UZFG-Y 2016 RIV GB eng J - Článek v odborném periodiku
    Čopíková, J. - Taubner, T. - Tůma, J. - Synytsya, A. - Dušková, Dagmar - Marounek, Milan
    Cholesterol and fat lowering with hydrophobic polysaccharide derivatives.
    Carbohydrate Polymers. Roč. 116, č. 1 (2015), s. 207-214. ISSN 0144-8617
    Institucionální podpora: RVO:67985904
    Klíčová slova: hydrophobically modified polysaccharides * structure * thermal analysis
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 4.219, rok: 2015

    Hydrophobic derivatives of highly methylated citrus pectin, chitosan and cellulose were prepared and tested as potential cholesterol lowering agents. Elemental analysis and spectroscopic methods confirmed high substitution degree for all of them. Substitution with long alkyl/acyl groups led to significant changes in physical and thermal properties of modified polysaccharides. Sorption of cholate and cholesterol by these polysaccharide-based sorbents was estimated in comparison with the synthetic drug cholestyramine. It was found that modified polysaccharides have high affinity to cholesterol. By contrast, cholestyramine was effective only in cholate sorption.
    Trvalý link: http://hdl.handle.net/11104/0258155