Počet záznamů: 1  

Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting

  1. 1.
    0456084 - ÚMCH 2017 RIV NL eng J - Článek v odborném periodiku
    Chen, Y. - Minh, L. V. - Liu, J. - Angelov, Borislav - Drechsler, M. - Garamus, V. M. - Willumeit-Römer, R. - Zou, A.
    Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting.
    Colloids and Surfaces B-Biointerfaces. Roč. 140, 1 April (2016), s. 74-82. ISSN 0927-7765
    Grant CEP: GA ČR(CZ) GC15-10527J
    Institucionální podpora: RVO:61389013
    Klíčová slova: baicalin * liposomes * folate receptor
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Impakt faktor: 3.887, rok: 2016

    Bioavailability of baicalin (BAI), an example of traditional Chinese medicine, has been modified by loading into liposome. Several liposome systems of different composition i.e., lipid/cholesterol (L), long-circulating stealth liposome (L-PEG) and folate receptor (FR)-targeted liposome (L-FA) have been used as the drug carrier for BAI. The obtained liposomes were around 80 nm in diameter with proper zeta potentials about -25 mV and sufficient physical stability in 3 months. The entrapment efficiency and loading efficiency of BAI in the liposomes were 41.0-46.4% and 8.8-10.0%, respectively. The morphology details of BAI lipsosome systems i.e., formation of small unilamellar vesicles, have been determined by cryogenic transmission electron microscopy (cryo-TEM) and small angle X-ray scattering (SAXS). In vitro cytotoxicity of BAI liposomes against HeLa cells was evaluated by MTT assay. BAI loaded FR-targeted liposomes showed higher cytotoxicity and cellular uptake compared with non-targeted liposomes. The results suggested that L-FA-BAI could enhance anti-tumor efficiency and should be an effective FR-targeted carrier system for BAI delivery.
    Trvalý link: http://hdl.handle.net/11104/0256677