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The Stationary-Phase Cells of Saccharomyces cerevisiae Display Dynamic Actin Filaments Required for Processes Extending Chronological Life Span
- 1.0455571 - MBÚ 2016 RIV US eng J - Článek v odborném periodiku
Vašicová, Pavla - Lejsková, Renata - Malcová, Ivana - Hašek, Jiří
The Stationary-Phase Cells of Saccharomyces cerevisiae Display Dynamic Actin Filaments Required for Processes Extending Chronological Life Span.
Molecular and Cellular Biology. Roč. 35, č. 22 (2015), s. 3892-3908. ISSN 0270-7306. E-ISSN 1098-5549
Grant CEP: GA ČR GAP305/12/0480
Institucionální podpora: RVO:61388971
Klíčová slova: MITOCHONDRIAL GENE-EXPRESSION * BUDDING YEAST * CALORIE RESTRICTION
Kód oboru RIV: CE - Biochemie
Impakt faktor: 4.427, rok: 2015
Stationary-growth-phase Saccharomyces cerevisiae yeast cultures consist of nondividing cells that undergo chronological aging. For their successful survival,the turnover of proteins and organelles, ensured by autophagy and the activation of mitochondria, is performed. Some of these processes are engaged in bythe actin cytoskeleton. In S. cerevisiae stationary-phase cells, F actin has been shown to form static aggregates named actin bodies, subsequently cited to be markers of quiescence. Our in vivo analyses revealed that stationary-phase cultures contain cells with dynamic actin filaments, besides the cells with static actin bodies. The cells with dynamic actin displayed active endocytosis and autophagy and well-developed mitochondrial networks. Even more,stationary-phase cell cultures grown under calorie restriction predominantly contained cells with actin cables, confirming that the presence of actin cables is linked to successful adaptation to stationary phase.
Trvalý link: http://hdl.handle.net/11104/0256207
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