Počet záznamů: 1  

Regulation of mitogen-activated protein kinase 3/1 activity during meiosis resumption in mammals

  1. 1. 0455078 - UZFG-Y 2016 RIV JP eng J - Článek v odborném periodiku
    Procházka, Radek - Blaha, Milan
    Regulation of mitogen-activated protein kinase 3/1 activity during meiosis resumption in mammals.
    Journal of Reproduction and Development. Roč. 61, č. 6 (2015), s. 495-502. ISSN 0916-8818
    Grant CEP: GA MZe(CZ) QJ1510138
    Institucionální podpora: RVO:67985904
    Klíčová slova: cumulus oocyte complexes * meiosis resumption * mitogen-activated protein kinase 3/1 (MAPK3/1)
    Kód oboru RIV: GI - Šlechtění a plemenářství hospodářských zvířat
    Impakt faktor: 1.453, rok: 2015

    In vivo, resumption of oocyte meiosis occurs in large ovarian follicles after the preovulatory surge of luteinizing hormone (LH). The LH surge leads to the activation of a broad signaling network in mural granulosa cells equipped with LH receptors. The signals generated in the mural granulosa cells are further augmented by locally produced peptides or steroids and transferred to the cumulus cell compartment and the oocyte itself. Over the last decade, essential progress has been made in the identification of molecular events associated with the final maturation and ovulation of mammalian oocytes. All new evidence argues for a multiple roles of mitogen-activated protein lcinase 3/1 (MAPK3/1) in the gonadotropin-induced ovulation processes. However, the knowledge of gonadotropin-induced signaling pathways leading to MAPK3/1 activation in follicular cells seems limited. To date, only the LH-induced transactivation of the epidermal growth factor receptor/MAPK3/1 pathway has been described in granulosa/cumulus cells even though other mechanisms of MAPK3/1 activation have been detected in other types of cells. In this review, we aimed to summarize recent advances in the elucidation of gonadotropin-induced mechanisms leading to the activation of MAPK3/1 in preovulatory follicles and cultured cumulus-oocyte complexes and to point out a specific role of this kinase in the processes accompanying final maturation of the mammalian oocyte.
    Trvalý link: http://hdl.handle.net/11104/0255717