Estrogen receptor beta (ERβ) in reproductive tract of male mice

0454478 - BTÚ 2016 US eng A - Abstrakt
Elzeinová, Fatima - Dostálová, Pavla - Děd, Lukáš - Dorosh, Andriy - Pěknicová, Jana
Estrogen receptor beta (ERβ) in reproductive tract of male mice.
Abstracts of the 14th International Symposium for Immunology of Reproduction “Progress in Reproductive Immunology”. Hoboken: American Journal of Reproductive Immunology, 2015 - (Mor, G.). s. 44. ISSN 1046-7408. E-ISSN 1600-0897.
[14th International Symposium for Immunology of Reproduction "progress in Reproductive Immunology". 22.05.2015-24.05.2015, Varna]
Grant CEP: GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR GA14-05547S
Institucionální podpora: RVO:86652036
Klíčová slova: estrogen receptor * testes * spermatozoa * monoclonal antibody
Kód oboru RIV: CE - Biochemie

The main production of estrogens in males is within the testes, where estrogens play role in control of spermatogenesis. Generally, estrogen action is mediated via binding and activation of estrogen receptors (ERs). Nowadays, two types of classical ERs (ERa,ERb) and several splice variants are known. These variants may directly mediate estrogen signalling, or they may modulate the function of full-length ERs. We focused our study on expression of ERb as a predominant variant of ERs in testes. According to our results, at least two variants of ERs mRNA are present in testes and spermatozoa. Further, we prepared specific monoclonal antibodies against these variants. More studies are needed to determine whether these variants are present within a single cell and can thus interact, or whether one type of cells preferentially express one ERb variant while another cell type express the second variant.
Trvalý link: http://hdl.handle.net/11104/0255886