Počet záznamů: 1  

Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer

  1. 1. 0451362 - UEM-P 2016 RIV US eng J - Článek v odborném periodiku
    McCullough, L. E. - Eng, S. M. - Bradshaw, P. T. - Cleveland, R. J. - Steck, S. E. - Terry, M. B. - Shen, J. - Crew, K.D. - Rössner ml., Pavel - Ahn, J. - Ambrosone, Ch.B. - Teitelbaum, S. L. - Neugut, A. I. - Santella, R. M. - Gammon, M. D.
    Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer.
    Annals of Epidemiology. Roč. 25, č. 4 (2015), s. 263-269. ISSN 1047-2797
    Institucionální podpora: RVO:68378041
    Klíčová slova: breast cancer * body mass index * oxidative stress * DNA repair * Epidemiology
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.335, rok: 2015

    We hypothesized that genetic variation in DNA repair and oxidative stress pathways may modify the obesity-postmenopausal breast cancer association. We observed multiplicative interactions (P ≤ 0.05) for eight gene polymorphisms in DNA repair and oxidative stress pathways for breast cancer risk. We conclude that obesity may be particularly deleterious for postmenopausal BC development in the presence of biologically plausible DNA repair or oxidative stress genotypes.
    Trvalý link: http://hdl.handle.net/11104/0252844