Počet záznamů: 1  

Phosphatidylinositol 4-kinases: Function, structure, and inhibition

  1. 1. 0449209 - UOCHB-X 2016 RIV US eng J - Článek v odborném periodiku
    Bouřa, Evžen - Nencka, Radim
    Phosphatidylinositol 4-kinases: Function, structure, and inhibition.
    Experimental Cell Research. Roč. 337, č. 2 (2015), s. 136-145. ISSN 0014-4827
    Grant CEP: GA ČR GJ15-21030Y; GA MŠk LO1302; GA ČR GA15-09310S
    GRANT EU: European Commission(XE) 333916 - STARPI4K
    Institucionální podpora: RVO:61388963
    Klíčová slova: phosphatidylinositol 4-kinase * inhibitor * crystal structure * virus
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.378, rok: 2015

    The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi. Humans have two type II PI4Ks (alpha and beta) and two type III enzymes (alpha and beta). Recently, the crystal structures were solved for both type II and type III kinase revealing atomic details of their function. Importantly, the type III PI4Ks are hijacked by +RNA viruses to create so-called membranous web, an extensively phosphorylated and modified membrane system dedicated to their replication. Therefore, selective and potent inhibitors of PI4Ks have been developed as potential antiviral agents. Here we focus on the structure and function of PI4Ks and their potential in human medicine.
    Trvalý link: http://hdl.handle.net/11104/0250870