Počet záznamů: 1  

A New Analogue of Locked Cyclohexane Nucleic Acids

  1. 1.
    0446581 - UOCHB-X 2016 RIV DE eng J - Článek v odborném periodiku
    Šála, Michal - Dejmek, Milan - Procházková, Eliška - Hřebabecký, Hubert - Rybáček, Jiří - Dračínský, Martin - Novák, Pavel - Rosenbergová, Šárka - Rosenberg, Ivan - Nencka, Radim
    A New Analogue of Locked Cyclohexane Nucleic Acids.
    Synthesis. Roč. 47, č. 17 (2015), s. 2654-2662. ISSN 0039-7881
    Grant CEP: GA ČR GPP207/12/P625; GA ČR GA13-26526S
    Institucionální podpora: RVO:61388963
    Klíčová slova: nucleosides * bicyclic compounds * oligonucleotides * carbocycles * medicinal chemistry
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.652, rok: 2015

    We report on a new analogue of locked cyclohexane nucleic acids that contains an adenine nucleobase at an alternative position and which resembles homo-DNA. The crucial locked carbocyclic nucleoside monomer was prepared with high enantioselectivity and was subsequently incorporated into a pair of modified oligonucleotides that were subjected to hybridization studies.
    Trvalý link: http://hdl.handle.net/11104/0248634