Počet záznamů: 1  

Lipid signaling in adipose tissue: Connecting inflammation & metabolism

  1. 1.
    0443441 - FGU-C 2016 RIV NL eng J - Článek v odborném periodiku
    Masoodi, M. - Kuda, Ondřej - Rossmeisl, Martin - Flachs, Pavel - Kopecký, Jan
    Lipid signaling in adipose tissue: Connecting inflammation & metabolism.
    Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. Roč. 1851, č. 4 (2015), s. 503-518. ISSN 1388-1981
    Grant CEP: GA ČR(CZ) GA13-00871S; GA MŠk(CZ) 7E12073; GA MŠk(CZ) LH14040
    Institucionální podpora: RVO:67985823
    Klíčová slova: adipocyte * futile substrate cycle * macrophage
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Impakt faktor: 4.779, rok: 2015

    Accumulation of immune cells, especially macrophages, and macrophage polarization from M2 to M1 state, affect intrinsic WAT signaling, namely anti-inflammatory and proinflammatory cytokines, fatty acids (FA), and lipid mediators derived from both n−6 and n−3 long-chain PUFA. Studies in mice suggest that (i) transient accumulation of M2 macrophages could be essential for the control of tissue FA levels during activation of lipolysis, (ii) currently unidentified M2 macrophage-borne signaling molecule(s) could inhibit lipolysis and re-esterification of lipolyzed FA back to triacylglycerols (TAG/FA cycle), and (iii) the egress of M2 macrophages from rebuilt WAT and removal of the negative feedback regulation could allow for a full unmasking of metabolic activities of adipocytes. Thus, M2 macrophages could support remodeling of WAT to a tissue containing metabolically flexible adipocytes endowed with a high capacity of both TAG/FA cycling and oxidative phosphorylation. This situation could be exemplified by a combined intervention using mild calorie restriction and dietary supplementation with EPA/DHA, which enhances the formation of “healthy” adipocytes
    Trvalý link: http://hdl.handle.net/11104/0246159