Počet záznamů: 1  

DNA and RNA Quadruplex-Binding Proteins

  1. 1. 0442425 - BFU-R 2015 CH eng J - Článek v odborném periodiku
    Brázda, Václav - Haroniková, Lucia - Liao, J.C.C. - Fojta, Miroslav
    DNA and RNA Quadruplex-Binding Proteins.
    International Journal of Molecular Sciences. Roč. 15, č. 10 (2014), s. 17493-17517. E-ISSN 1422-0067
    Grant CEP: GA ČR(CZ) GBP206/12/G151
    Institucionální podpora: RVO:68081707
    Klíčová slova: DNA quadruplex * RNA quadruplex * telomere
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 2.862, rok: 2014

    Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i-Motifs, minor groove quadruplexes, G-quadruplexes, etc.), the best described are G-quadruplexes which are featured by Hoogsteen base-paring. Sequences with the potential to form quadruplexes are widely present in genome of all organisms. They are found often in repetitive sequences such as telomeric ones, and also in promoter regions and 5' non-coding sequences. Recently, many proteins with binding affinity to G-quadruplexes have been identified. One of the initially portrayed G-rich regions, the human telomeric sequence (TTAGGG)(n), is recognized by many proteins which can modulate telomerase activity. Sequences with the potential to form G-quadruplexes are often located in promoter regions of various oncogenes. The NHE III1 region of the c-MYC promoter has been shown to interact with nucleolin protein as well as other G-quadruplex-binding proteins. A number of G-rich sequences are also present in promoter region of estrogen receptor alpha.
    Trvalý link: http://hdl.handle.net/11104/0245240