Počet záznamů: 1  

Altered expression of the voltage-gated calcium channel subunit alpha(2)delta-1: A comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain

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    0439333 - FGÚ 2015 RIV GB eng J - Článek v odborném periodiku
    Nieto-Rostro, M. - Sandhu, G. - Bauer, C. S. - Jiruška, Přemysl - Jefferys, J. G. R. - Dolphin, A. C.
    Altered expression of the voltage-gated calcium channel subunit alpha(2)delta-1: A comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain.
    Neuroscience. Roč. 283, Dec (2014), s. 124-137. ISSN 0306-4522. E-ISSN 1873-7544
    Grant CEP: GA MZd(CZ) NT14489
    Institucionální podpora: RVO:67985823
    Klíčová slova: calcium channel * dorsal root ganglion (DRG) * alpha2delta subunit * epilepsy * neuropathic pain * reactive gliosis
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.357, rok: 2014

    In this study we examined whether the level or distribution of a2d-1 was altered in the hippocampus following experimental induction of epileptic seizures in rats, using both the kainic acid model of human temporal lobe epilepsy, in which status epilepticus is induced, and the tetanus toxin model in which status epilepticus is not involved. The main finding of this study is that we did not identify somatic overexpression of a2d-1 in hippocampal neurons in either of the epilepsy models, unlike the upregulation of a2d-1 that occurs following peripheral nerve damage to both somatosensory and motor neurons
    Trvalý link: http://hdl.handle.net/11104/0242629

     
     
Počet záznamů: 1  

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