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Gairo virus, a novel arenavirus of the widespread Mastomys natalensis: Genetically divergent, but ecologically similar to Lassa and Morogoro viruses

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    0438671 - ÚBO 2016 RIV US eng J - Článek v odborném periodiku
    Gryseels, S. - Rieger, T. - Oestereich, L. - Cuypers, B. - Borremans, B. - Makundi, R. - Leirs, H. - Günther, S. - Goüy de Bellocq, Joëlle
    Gairo virus, a novel arenavirus of the widespread Mastomys natalensis: Genetically divergent, but ecologically similar to Lassa and Morogoro viruses.
    Virology. Roč. 476, February (2015), s. 249-256. ISSN 0042-6822. E-ISSN 1089-862X
    Grant CEP: GA ČR GCP502/11/J070; GA MŠMT EE2.3.20.0303
    Institucionální podpora: RVO:68081766
    Klíčová slova: Arenavirus * Mastomys natalensis * Tanzania * Virology * Phylogeny * Ecology * Zoonotic infections * Hemorrhagic fevers
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 3.200, rok: 2015

    Despite its near pan-African range, the Natal multimammate mouse, Mastomys natalensis, carries the human pathogen Lassa virus only in West Africa, while the seemingly non-pathogenic arenaviruses Mopeia, Morogoro, and Luna have been detected in this semi-commensal rodent in Mozambique/Zimbabwe, Tanzania and Zambia, respectively. Here, we describe a novel arenavirus in M. natalensis from Gairo district of central Tanzania, for which we propose the name "Gairo virus". Surprisingly, the virus is not closely related with Morogoro virus that infects M. natalensis only 90 km south of Gairo, but clusters phylogenetically with Mobala-like viruses that infect non-M. natalensis host species in Central African Republic and Ethiopia. Despite the evolutionary distance, Gairo virus shares basic ecological features with the other M. natalensis-borne viruses Lassa and Morogoro. Our data show that M. natalensis, carrying distantly related viruses even in the same geographical area, is a potent reservoir host for a variety of arenaviruses.
    Trvalý link: http://hdl.handle.net/11104/0242084

     
     
Počet záznamů: 1  

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