0436669 - ÚEM 2015 RIV US eng J - Článek v odborném periodiku
Anděrová, Miroslava - Benešová, Jana - Mikešová, Michaela - Džamba, Dávid - Honsa, Pavel - Kriška, Ján - Butenko, Olena - Novosadová, Vendula - Valihrach, Lukáš - Kubista, Mikael - Dmytrenko, L. - Cicanič, M. - Vargová, L.
Altered Astrocytic Swelling in the Cortex of α-Syntrophin-Negative GFAP/EGFP Mice.
PLoS ONE. Roč. 9, č. 11 (2014), e113444. ISSN 1932-6203. E-ISSN 1932-6203
Grant CEP: GA ČR GA13-02154S; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) ED1.1.00/02.0109
Grant ostatní: GA MŠk(CZ) CZ.1.07/2.3.00/30.0045
Institucionální podpora: RVO:68378041 ; RVO:86652036
Klíčová slova: astrocyte volume regulation * aquaporines * extracellular space
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.234, rok: 2014
DOI: https://doi.org/10.1371/journal.pone.0113444

In the present study we quantified cell volume changes in astrocytes lacking α-syntrophin thanks to the successful generation of GFAP/EGFP/α-Syn-/- mice, which enabled us to visualize astrocytes based on EGFP expression. We demonstrated that α-syntrophin knockout results in smaller astrocytic swelling when induced by severe hypoosmotic stress, OGD or high extracellular K+, and it also affects astrocyte volume changes during the washout period following mild hypo- and hyperosmotic stress, and 10 mMK+.
Trvalý link: http://hdl.handle.net/11104/0240347