Počet záznamů: 1  

Phthalates Deregulate Cell Proliferation, but Not Neuroendocrine Transdifferentiation, in Human LNCaP Prostate Cancer Cell Model

  1. 1. 0435171 - BFU-R 2015 RIV CZ eng J - Článek v odborném periodiku
    Hrubá, Eva - Pernicová, Zuzana - Palková, L. - Souček, Karel - Vondráček, Jan - Machala, M.
    Phthalates Deregulate Cell Proliferation, but Not Neuroendocrine Transdifferentiation, in Human LNCaP Prostate Cancer Cell Model.
    Folia Biologica. Roč. 60, č. 2014 (2014), s. 56-61. ISSN 0015-5500
    Grant CEP: GA MŠk(CZ) EE2.3.30.0030; GA MŠk(CZ) ED1.100/02/0123
    Institucionální podpora: RVO:68081707
    Klíčová slova: phthalates * prostate cancer cells * cell cycle modulation
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 1.000, rok: 2014

    Phthalate esters are ubiquitous environmental pollutants widely used as plasticizers, which have been shown to interfere with both endocrine regulation and development of reproductive organs. In the present study, we examined the impact of diethylhexyl phthalate (DEHP) and dibutyl phthalate (DBP) on the proliferation of androgen-sensitive human prostate carcinoma LNCaP cells and related events. The results showed that both compounds were able to inhibit cell cycle progression in a dose-dependent manner. However, only DEHP was found to weakly reduce androgen receptor (AR) protein levels after long-term exposure, while only DBP partially inhibited expression of the prostate-specific antigen (KLK3) gene, a model AR transcriptional target. This indicated that inhibition of cell proliferation was likely independent of any AR modulations. Both phthalates induced suppression of cell proliferation, but none of them affected the levels of markers associated with neuroendocrine transdifferentiation (NED) in LNCaP cells.
    Trvalý link: http://hdl.handle.net/11104/0239096