Počet záznamů: 1  

cis-trans Isomerization of silybins A and B

  1. 1. 0432999 - MBU-M 2015 RIV DE eng J - Článek v odborném periodiku
    Novotná, Michaela - Gažák, Radek - Biedermann, David - Di Meo, F. - Marhol, Petr - Kuzma, Marek - Bednárová, Lucie - Fuksová, Kateřina - Trouillas, P. - Křen, Vladimír
    cis-trans Isomerization of silybins A and B.
    Beilstein Journal of Organic Chemistry. -, č. 10 (2014), s. 1047-1063. ISSN 1860-5397
    Grant CEP: GA ČR GAP207/10/0288; GA MŠk LH13097; GA MŠk(CZ) LD13041
    Institucionální podpora: RVO:61388971 ; RVO:61388963
    Klíčová slova: isomerization * silibinin * silybin
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.762, rok: 2014

    Methods were developed and optimized for the preparation of the 2,3-cis- and the 10,11-cis-isomers of silybin by the Lewis acid catalyzed (BF3 center dot OEt2) isomerization of silybins A (1a) and B (1b) (trans-isomers). The absolute configuration of all optically pure compounds was determined by using NMR and comparing their electronic circular dichroism data with model compounds of known absolute configurations. Mechanisms for cis-trans-isomerization of silybin are proposed and supported by quantum mechanical calculations
    Trvalý link: http://hdl.handle.net/11104/0237298