Počet záznamů: 1  

DNA-dependent protein kinase and its inhibition in support of radiotherapy

  1. 1.
    0394806 - BFU-R 2014 RIV GB eng J - Článek v odborném periodiku
    Novotná, E. - Tichý, Adam - Pejchal, J. - Lukášová, Emilie - Salovská, B. - Vávrová, J.
    DNA-dependent protein kinase and its inhibition in support of radiotherapy.
    International Journal of Radiation Biology. Roč. 89, č. 6 (2013), s. 416-423. ISSN 0955-3002
    Institucionální podpora: RVO:68081707
    Klíčová slova: DOUBLE-STRAND BREAK * CANCER-CELLS * REPAIR INHIBITION
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 1.837, rok: 2013

    Purpose : Radiotherapy has been used as a treatment of almost 50% of all malignant tumors. The aim of this review is to provide a comprehensive overview of the recent knowledge in the field of molecular mechanisms of radiation-induced double-stranded breaks (DSB) repair. This paper gives particular emphasis to a key DNA repair enzyme, DNA-dependent protein kinase (DNA-PK), which plays a pivotal role in non-homologous end-joining. Furthermore, we discuss possibilities of DNA-PK inhibition and other molecular approaches employed in order to facilitate radiotherapy.
    Trvalý link: http://hdl.handle.net/11104/0222969