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A Broad Phylogenetic Survey Unveils the Diversity and Evolution of Telomeres in Eukaryotes

  1. 1.
    0392621 - BFU-R 2014 RIV GB eng J - Článek v odborném periodiku
    Fulnečková, Jana - Ševčíková, Tereza - Fajkus, Jiří - Lukešová, Alena - Lukeš, Martin - Vlček, Čestmír - Lang, B.F. - Kim, E. - Eliáš, M. - Sýkorová, Eva
    A Broad Phylogenetic Survey Unveils the Diversity and Evolution of Telomeres in Eukaryotes.
    Genome Biology and Evolution. Roč. 5, č. 3 (2013), s. 468-483. ISSN 1759-6653
    Grant CEP: GA ČR(CZ) GA521/09/1912
    Grant ostatní:GA ČR(CZ) GAP506/10/0705; GA MŠk(CZ) ED1.1.00/02.0068
    Program:GA; ED
    Výzkumný záměr: CEZ:AV0Z50040702; CEZ:AV0Z60660521
    Institucionální podpora: RVO:68081707 ; RVO:60077344 ; RVO:61388971 ; RVO:68378050
    Klíčová slova: MOLECULAR PHYLOGENY * SEQUENCE DATA * GENOME
    Kód oboru RIV: BO - Biofyzika; EE - Mikrobiologie, virologie (MBU-M); EB - Genetika a molekulární biologie (UMG-J)
    Impakt faktor: 4.532, rok: 2013

    Telomeres, ubiquitous and essential structures of eukaryotic chromosomes, are known to come in a variety of forms, but knowledge about their actual diversity and evolution across the whole phylogenetic breadth of the eukaryotic life remains fragmentary. To fill this gap, we employed a complex experimental approach to probe telomeric minisatellites in various phylogenetically diverse groups of algae. Our most remarkable results include the following findings: 1) algae of the streptophyte class Klebsormidiophyceae possess the Chlamydomonas-type telomeric repeat (TTTTAGGG) or, in at least one species, a novel TTTTAGG repeat, indicating an evolutionary transition from the Arabidopsis-type repeat (TTTAGGG) ancestral for Chloroplastida; 2) the Arabidopsis-type repeat is also present in telomeres of Xanthophyceae, in contrast to the presence of the human-type repeat (TTAGGG) in other ochrophytes studied, and of the photosynthetic alveolate Chromera velia, consistent with its phylogenetic position close to apicomplexans and dinoflagellates; 3) glaucophytes and haptophytes exhibit the human-type repeat in their telomeres; and 4) ulvophytes and rhodophytes have unusual telomere structures recalcitrant to standard analysis.
    Trvalý link: http://hdl.handle.net/11104/0221440