Počet záznamů: 1  

Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4

  1. 1. 0391838 - UMCH-V 2014 RIV GB eng J - Článek v odborném periodiku
    Kolenko, Petr - Koch, B. - Rahfeld, J.-U. - Schilling, S. - Demuth, H.-U. - Stubbs, M. T.
    Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4.
    Acta Crystallographica Section F. Roč. 69, č. 4 (2013), s. 358-361. ISSN 1744-3091
    Grant CEP: GA MŠk EE2.3.30.0029
    Institucionální podpora: RVO:61389013
    Klíčová slova: glutaminyl cyclases * Drosophila melanogaster * soaking
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 0.568, rok: 2013

    The structure of ligand-free glutaminyl cyclase (QC) from Drosophila melanogaster (DmQC) has been determined in a novel crystal form. The protein crystallized in space group I4, with unit-cell parameters a = b = 122.3, c = 72.7 Å. The crystal diffracted to a resolution of 2 Å at the home source. The structure was solved by molecular replacement and was refined to an R factor of 0.169. DmQC exhibits a typical α/β-hydrolase fold. The electron density of three monosaccharides could be localized. The accessibility of the active site will facilitate structural studies of novel inhibitor-binding modes.
    Trvalý link: http://hdl.handle.net/11104/0221172