Počet záznamů: 1  

Effect of fluoxetine and adenosine receptor NECA agonist on G alpha q/11 protein of C6 glioma cells

  1. 1. 0390643 - FGU-C 2013 RIV SE eng J - Článek v odborném periodiku
    Kovářů, H. - Kovářů, F. - Lisá, Věra
    Effect of fluoxetine and adenosine receptor NECA agonist on G alpha q/11 protein of C6 glioma cells.
    Neuroendocrinology Letters. Roč. 33, č. 6 (2012), s. 614-618. ISSN 0172-780X
    Institucionální podpora: RVO:67985823
    Klíčová slova: C6 glioma cells * SSRI antidepressant * G alpha q/11 signalling * G protein coupled receptor
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 0.932, rok: 2012

    In C6 glioma cells, we studied acute administration of SSRI antidepressants - fluoxetine, sertraline and citalopram. We used immunochemical estimation (ELISA) of the main types of G-protein alpha subunits from isolated membranes of C6 glioma cells. We also estimated effect of NECA agonist on fluoxetine induced signalling via 1,4,5 IP3 and its levels. Presented data are first findings about adenosine receptor interaction with fluoxetine signalling. Thus in vitro studies contribute to the clarification of the molecular basis of antidepressant action
    Trvalý link: http://hdl.handle.net/11104/0219516