Počet záznamů: 1  

Isotope exchange reactions of the hydrogen H-5 of selected pyrimidine derivatives and the preparation of tritium-labeled pyrimidines

  1. 1. 0388747 - UOCHB-X 2013 RIV CZ eng J - Článek v odborném periodiku
    Dračínský, Martin - Jansa, Petr - Elbert, Tomáš
    Isotope exchange reactions of the hydrogen H-5 of selected pyrimidine derivatives and the preparation of tritium-labeled pyrimidines.
    Collection of Czechoslovak Chemical Communications. Roč. 76, č. 12 (2011), s. 1567-1577. ISSN 0010-0765
    Grant CEP: GA AV ČR KJB400550903; GA MŠk 1M0508
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: isotopic labeling * NMR spectroscopy * nucleobases * pyrimidines
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 1.283, rok: 2011

    The hydrogen-to-deuterium isotope exchange reaction of hydrogen in position 5 of pyrimidine derivatives was studied using NMR techniques. The dependence of the reaction rate on the pH and on the solvent composition was explored. In tracer experiments using tritiated water, the application of this exchange reaction was tested for the preparation of pyrimidine derivatives labeled by tritium.
    Trvalý link: http://hdl.handle.net/11104/0217699