Počet záznamů: 1  

Enzymatic Glycosylation of Small Molecules: Challenging Substrates Require Tailored Catalysts

  1. 1.
    0381774 - MBU-M 2013 RIV DE eng J - Článek v odborném periodiku
    Desmet, T. - Soetaert, W. - Bojarová, Pavla - Křen, Vladimír - Dijkhuizen, L. - Eastwick-Field, V. - Schiller, A.
    Enzymatic Glycosylation of Small Molecules: Challenging Substrates Require Tailored Catalysts.
    Chemistry - A European Journal. Roč. 18, č. 35 (2012), s. 10786-10801. ISSN 0947-6539
    Institucionální podpora: RVO:61388971
    Klíčová slova: acceptor specificity * enzyme engineering * glycosylation
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 5.831, rok: 2012

    Glycosylation can significantly improve the physicochemical and biological properties of small molecules like vitamins, antibiotics, flavors, and fragrances. The chemical synthesis of glycosides is, however, far from trivial and involves multistep routes that generate lots of waste. In this review, biocatalytic alternatives are presented that offer both stricter specificities and higher yields. The advantages and disadvantages of different enzyme classes are discussed and illustrated with a number of recent examples. Progress in the field of enzyme engineering and screening are expected to result in new applications of biocatalytic glycosylation reactions in various industrial sectors
    Trvalý link: http://hdl.handle.net/11104/0212166