Ticks: Disease, Management and Control

0378623 - BC 2013 RIV US eng M - Část monografie knihy
Langhansová, Helena - Chagas, A. C. - Andersen, J. F. - Kopecký, Jan - Kotsyfakis, Michalis
Tick saliva-mediated immunomodulation of the vertebrate host.
Ticks: Disease, Management and Control. New York: Nova Science Publishers, Inc, 2012 - (Woldemeskel, M.), s. 19-36. Insects and Other Terrestrial Arthropods: Biology, Chemistry and Behavior. ISBN 978-1-62081-136-8
Grant CEP: GA ČR GCP302/11/J029; GA MŠMT(CZ) LC06009; GA ČR GAP502/12/2409
Výzkumný záměr: CEZ:AV0Z60220518
Klíčová slova: tick infestation * host system modulation * bioactive molecules * tick-borne pathogens * saliva-assisted transmission
Kód oboru RIV: EC - Imunologie
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The feeding period of hard ticks often exceeds one week and makes tick infestation a considerable intervention to host physiology. A broad range of inflammatory and immune reactions take place locally at the feeding site as well as systemically within the host body. Active modulation of the host immune response by tick saliva is thus required for the tick to complete its blood meal. Upon attachment, the tick inoculates its saliva containing a repertoire of bioactive molecules that help ticks to attach to the host, to overcome host hemostasis, and to prevent host pain and itching and the concomitant scratching. Furthermore, the tick must deal with the host innate immunity during primary infestation and with innate and adaptive immunity in subsequent infestations. The immunomodulatory properties of tick saliva and the roles of individual salivary components at the tick-host interface are described in this chapter, dealing with virtually all levels of nonspecific and specific host immune mechanisms. In addition, tick-borne pathogens, including the Lyme disease spirochete Borrelia burgdorferi, exploit the pharmacologic activities of tick salivary molecules to successfully maintain their life cycle. Identification of molecules responsible for this phenomenon, termed saliva-assisted transmission (SAT), can help in the design of an efficient transmission-blocking vaccine. Moreover, understanding of the immunity-based processes within the tick-host-pathogen interface opens a relatively new field for the development of drugs to treat various immunity-related diseases.
Trvalý link: http://hdl.handle.net/11104/0210047