Počet záznamů: 1  

Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells

  1. 1. 0373440 - BC-A 2012 RIV GB eng J - Článek v odborném periodiku
    Slámová, M. - Skallová, A. - Páleníková, J. - Kopecký, Jan
    Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells.
    Parasite immunology. Roč. 33, č. 12 (2011), 654-660. ISSN 0141-9838
    Grant CEP: GA AV ČR IAA600960811; GA MŠk(CZ) LC06009
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: Borrelia * dendritic cell * immune modulation * Ixodes ricinus
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 2.601, rok: 2011

    Interaction between mouse dendritic cells (DCs) and Borrelia afzelii spirochetes was monitored on three different levels: phagocytosis of spirochetes by DCs, production of cytokines by Borrelia-stimulated DCs and the ability of Borrelia-exposed DCs to activate specific CD4+ T lymphocytes. The effect of Ixodes ricinus tick saliva on each of these interactions was examined. Tick saliva was shown to decrease the number of phagocytosing DCs. The ability of Borrelia-exposed DCs to induce both proliferation and IL-2 production by specific CD4+ T cells was significantly reduced by tick saliva. And surprisingly, we have shown an inhibitory effect of tick saliva on the production of both Th1 (TNF-alpha and IL-6) and Th2 (IL-10) cytokines by DCs. Our data reveal a complex inhibitory effect of tick saliva on Borrelia-DCs interaction.
    Trvalý link: http://hdl.handle.net/11104/0206540