Intensification of the Use of Ionic Liquids as Efficient Reaction Co-Solvents in Asymmetric Hydrogenations

0361523 - ÚCHP 2012 RIV CH eng J - Článek v odborném periodiku
Černá, I. - Klusoň, Petr - Bendová, Magdalena - Floriš, Tomáš - Pelantová, Helena - Pekárek, T.
Intensification of the Use of Ionic Liquids as Efficient Reaction Co-Solvents in Asymmetric Hydrogenations.
Chemical Engineering and Processing: Process Intensification. Roč. 50, č. 3 (2011), s. 264-272. ISSN 0255-2701. E-ISSN 1873-3204
Grant CEP: GA AV ČR KAN400720701; GA AV ČR IAA400720710
Výzkumný záměr: CEZ:AV0Z40720504; CEZ:AV0Z50200510
Klíčová slova: Ionic liquids * asymmetric hydrogenations * BmimPF6
Kód oboru RIV: CI - Průmyslová chemie a chemické inženýrství
Impakt faktor: 1.924, rok: 2011

The complex treatment of the reaction system must be always accepted whenever a genuine role of an ionic liquid is discussed. For this purpose a well understood reaction system asymmetric hydrogenation of methyl-3-oxobutanoate (methylacetoacetate/MAA) to methyl-3-hydroxybutanoate (methylhydroxybutyrate/MHB) over the chiral Noyori type Ru-BINAP catalyst in the ethanol-bmimPF(6) reversibly biphasic mixed phase was chosen. Self-prepared bmimPF(6) ionic liquid was exposed to a series of normalized purification steps based on a theoretical semi-mechanistic model. It provided a clear evidence of the number and duration of necessary purification steps together with an effective value of each of them. Another important data were collected in the form of pseudo-ternary phase diagrams for all major components including the model impurities.
Trvalý link: http://hdl.handle.net/11104/0198821